Successful treatments for persistent and chronic Lyme and tick-borne diseases are rapidly emerging.
We’ll keep this page updated with the latest treatment information.
Stanford University has been screening existing drugs for more effective treatment of chronic Lyme disease since 2011. In 2016, they published a list of 20 top (already available) drugs that far exceed the effectiveness of current treatments. They moved these drugs into animal studies. Over the last few years, two drugs have surfaced – Disulfiram and Azlocillin. Disulfiram is available now. Azlocillin is approved, but not yet available in the U.S. Azlocillin has been effective in killing drug-tolerant forms of B. burgdorferi in lab dishes. The side effects of this drug are minimal. Stanford patented the compound and is working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial. This could be a real breakthrough!
Dapsone Combination Therapy:
Johns Hopkins Ying Zhang (MD, Ph.D.) has been very busy investigating better treatment strategies for persistent Lyme disease, finding that treatments for persistent tuberculosis have potential in chronic Lyme. Clinical studies were published this year revealing successful outcomes. This is a viable treatment option available now.
Ken Liegner, MD, took Stanford research into clinical practice in 2020 – publishing his research with 70 patients. While the regimen is VERY difficult (any exposure to alcohol can create serious effects), many patients have resolved their symptoms, especially cognitive, and been able to live antibiotic-free with restored quality of life. Facebook groups tracking patient responses have emerged to support the patient journey with disulfiram. Here is one such group. Here is another.
The inflammatory aspect of Lyme and tick-borne diseases has been known for a long time, but only recently has Mast Cell Activation Syndrome/Disorder landed on the map for most Lyme practitioners. Addressing MCAS has been life-changing for many Lyme patients and has created a pathway to improved quality of life, improving tolerance and effectiveness of treatment.
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